Iron infusion and newer intravenous iron formulations

Chemical reactions of vitamin C with intravenous-iron formulations.

BACKGROUND Intravenous (IV) iron is widely prescribed for patients on haemodialysis, to replace iron losses during treatment. It releases labile iron, which can induce oxidation of vitamin C and trigger oxidant damage. We examined the stability of vitamin C in the presence of IV iron compounds. We further examined in the ability of vitamin C to release iron from these compounds. METHODS Vitam...

Performance of Redox Active and Chelatable Iron Assays to Determine Labile Iron Release From Intravenous Iron Formulations

Emerging data from global markets outside the United States, where many generic iron sucrose formulations are available, have revealed that non-US generic intravenous (i.v.) iron formulations may have iron release profiles that differ from the reference listed drug (RLD). The first generic i.v. iron approved in the United States was sodium ferric gluconate complex in 2011. We evaluated chelatab...

Reactions to Total Dose Intravenous Infusion of Iron Dextran (imferon).

Iron metabolism; utilization of intravenous radioactive iron.

T HE HUMAN body shows great economy in its handling of iron. Only small amounts of iron arefound in the excreta, and these amounts cannot be appreciably increased through loading body iron stores by oral ingestion,’ by parenteral iron administration2 or by multiple blood transfusions.3 These observations imply that iron is rigidly conserved by the body and that no attention need be directed tow...

Iron Metabolism Utilization of Intravenous Radioactive Iron

T HE HUMAN body shows great economy in its handling of iron. Only small amounts of iron arefound in the excreta, and these amounts cannot be appreciably increased through loading body iron stores by oral ingestion,’ by parenteral iron administration2 or by multiple blood transfusions.3 These observations imply that iron is rigidly conserved by the body and that no attention need be directed tow...